Treatment of serious anaerobic & some Staph & Strep infections; prophylaxis of endocarditis & surgical infection.
Dosage/Direction for Use
AdultSerious infections 150-300 mg 6 hrly. More severe infections 300-450 mg 6 hrly. Acne 150 mg 12 hrly. Bacterial vaginosis 300 mg 12 hrly for 7 days. Cervicitis due toChlamydia trachomatis 450 mg 6 hrly for 10-14 days. Pelvic inflammatory disease (inpatient treatment) Initially clindamycin IV 900 mg 8 hrly + gm -ve aerobic antibiotic IV spectrum for at least 4 days & 48 hr after patient improves then continue w/ oral clindamycin HCl 450 mg 6 hrly for 10-14 days. Prevention of bacterial endocarditis in penicillin-allergic patients 600 mg as a single dose 1 hr prior to the procedure. Pneumocystis jirovecii (carinii)pneumonia in AIDS patients 300-450 mg 6 hrly + primaquine for 21 days. Alternative treatment of multidrug resistantPlasmodium falciparuminfection 20 mg/kg/day divided in 3 equal doses + quinine or amodiaquine for at least 5 days.
Administration
May be taken with or without food: Take w/ full glass of water to avoid esophageal irritation.
Contraindications
Hypersensitivity to clindamycin or lincomycin. Development of pseudomembranous colitis. Newborn (infants <30 days).
Special Precautions
Not for the treatment of nonbacterial infections & meningitis. Clostridium difficile-associated diarrhea (CDAD). Atopic individuals as well as history of GI disease particularly colitis. Concurrent use w/ neuromuscular blocking agents. G6PD deficiency. Perform blood exam during therapy w/ primaquine & surgical drainage & necrotic tissue removal in combination w/ antibiotic therapy. Severe renal &/or hepatic impairment accompanied by severe metabolic aberrations. Monitor serum levels for high-dose therapy. Periodic blood counts, liver & kidney function tests during prolonged therapy. Increased risk of antibiotic resistance. Overgrowth of nonsusceptible organisms including fungi; liver function tests abnormalities. Pregnancy & lactation. Childn ≤16 yr. Elderly >60 yr.
Sign Out
